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Tittle : Synthesis and anticonvulsant activity of some semicarbazone derivatives of some carbonyl compounds

Author(s) : Ashok Kumar*, S. B. Singh, Galal M. Zaiad, Ismail Awheda

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Abstract:

A search of new potent anticonvulsant drugs continues to be an active area of investigation in medicinal chemistry. Although several new anticonvulsant drugs are already in clinical use, some types of seizures are still not adequately treated with current therapy and have limitations, intolerable side effects. Keeping this in mind, the present work was carried out to synthesize a series of semicarbazones to get the compound with lesser side effects and more potent anticonvulsive agents. The present study describes the synthesis of newer semicarbazone derivatives by the condensation reaction of ketones and semicarbazides and their anticonvulsant activity was tested by using standard maximal electroshock (MES) induced seizures in mice and subcutaneous strychnine threshold test (ScSty) in rats using dose 100 mg/kg, intraperitoneally, and neurotoxicity screening was assessed by applying rotarod test in mice. Most of the compound exhibited potent anticonvulsant activity and more safer than the standard drug, phenetoin. Among all compounds, compounds SCZ3 & SCZ4 produced most potent anticonvulsant effect.

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